Preliminary Agenda
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Thursday, September 18, 2008
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8:30 am
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NIAID Welcome Address
Catherine, Laughlin, Ph.D. (NIAID)
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8:35 am
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NIAID Resources and Opportunities for Dengue Research
Cristina Cassetti, Ph.D. (NIAID)
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Session I: Animal Models to Study Dengue Pathogenesis
Chairs: Eva Harris and Rebeca Rico-Hesse
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8:50 am
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Human Pathogenesis and Mouse Models
Alan Rothman, M.D. (University of Massachusetts Medical School)
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9:30 am
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Dengue Disease and Immunity in Humanized Mice
Rebeca Rico-Hesse, Ph.D., M.P.H. (Southwest Foundation for Biomedical Research)
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10:00 am
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Dengue Viral Pathogenesis and Immune Response in Humanized (RAG-hu) Mice
Ramesh Akkina, Ph.D. (Colorado State University)
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10:30 am
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Morning Break
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11:00 am
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The AG129 Mouse Model for Dengue Virus Infection and Disease
Eva Harris, Ph.D. (University of California, Berkeley)
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11:30 am
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A Mouse Model to Investigate T-cell Response to Dengue Virus
Sujan Shresta, Ph.D. (La Jolla Institute for Allergy and Immunology)
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12:00 am
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Discussion
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12:30 pm
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Lunch break
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2:00 pm
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The Rhesus Macaque Model of DHF/DSS: How Close Are We to Human Disease?
Anna Durbin, M.D. (Johns Hopkins Bloomberg School of Public Health)
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2:30 pm
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Passive Immunization in Monkeys Using Monoclonal Antibodies Against Dengue Virus
Ana Goncalvez, Ph.D. (Laboratory of Infectious Diseases, NIAID)
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3:00 pm
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Yucatan Miniature Swine as an Immunogenicity and Infection Model for Dengue
Tim Burgess (Naval Medical Research Center)
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3:00 pm
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Discussion
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4:00 pm
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Afternoon Break
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Session II: Animal Models to Evaluate Dengue Vaccines and Therapeutics
Chairs: Anna Durbin and Stephen Whitehead
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4:30 pm
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Evaluation of Attenuated Viruses in Mice and Monkeys
Stephen Whitehead, Ph.D. (Laboratory of Infectious Diseases, NIAID)
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5:00 pm
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Dengue Vaccine, Monkey Animal Models and Sanofi Pasteur R&D Experience
Thierry Decelle, DVM (Sanofi Pasteur) |
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5:30 pm
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Discussion
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6:00 pm
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Adjourn
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Friday, September 19, 2008
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Session II, Continued: Animal Models to Evaluate Dengue Vaccines and Therapeutics
Chairs: Anna Durbin and Steve Whitehead
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8:30 am
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Evaluation of Reproductive Toxicity of a Dengue Live-attenuated Vaccine Candidate in Mice
Sandra Giannini, Ph.D. (GlaxoSmithKline) |
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9:00 am
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Dengue Vaccine Candidate Characterization Using Monkeys
Kenneth Eckels, Ph.D. (Walter Reed Army Institute of Research) |
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9:30 am
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Evaluation of Anti-viral Drug Candidates in Dengue Mouse Models
Wouter Schul, Ph.D. (Novartis Institute for Tropical Diseases)
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10:00 am
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FDA Perspective
Lewis Markoff, M.D. (CBER, FDA)
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10:15 am
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Morning Break
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Session III: Roundtable Discussion and Group Recommendations
Chairs: Cristina Cassetti and John Roehrig
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10:30 am
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Summary of NHP models
Anna Durbin and Stephen Whitehead
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11:00 am
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Summary of Models for Vaccines
Stephen Whitehead and Anna Durbin
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11:30 am
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Summary of Pathogenesis
Scott Halstead and Alan Rothman
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12:00 pm
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Pick Up Box Lunch
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12:30 pm
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Summary of Murine Models
Eva Harris, Rebeca Rico-Hesse and Leonard Schultz
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1:00 pm
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Summary of Models for Therapeutics
Wouter Schul and Michael Diamond
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1:30 pm
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Discussion
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2:30 pm |
Adjourn
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